ZIAC (Bisoprolol Fumarate and Hydrochlorothiazide) Tablets
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چکیده
Bisoprolol fumarate is chemically described as (±)-1-[4-[[2-(1 methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol(E)-2-butenedioate (2:1) (salt). It possesses an asymmetric carbon atom in its structure and is provided as a racemic mixture. The S(-) enantiomer is responsible for most of the beta-blocking activity. Its empirical formula is (C18H31NO4)2•C4H4O4 and it has a molecular weight of 766.97. Its structural formula is:
منابع مشابه
Simultaneous Spectrophotometric Estimation of Hydrochlorothiazide and Bisoprolol Fumarate in Combined Dosage Forms
Rapid, precise, accurate, and specific ratiospectra derivative spectrophotometry and a simple UV spectrophotometry using simultaneous equation methods are developed for the simultaneous determination of bisoprolol fumarate and hydrochlorothiazide from combined pharmaceutical dosage forms. For ratiospectra derivative spectrophotometry, the amplitudes were measured at 202.6 nm for bisoprolol fuma...
متن کاملUse of Response Surface Methodology in the Formulation and Optimization of Bisoprolol Fumarate Matrix Tablets for Sustained Drug Release
The aim of this investigation was to develop and optimize bisoprolol fumarate matrix tablets for sustained release application by response surface methodology based on 2(3) factorial design. The effects of the amounts of calcium alginate, HPMC K4M, and Carbopol 943 in bisoprolol fumarate matrix tablets on the properties of bisoprolol fumarate sustained release matrix tablets like drug release a...
متن کاملSimultaneous Spectrophotometric Estimation of Bisoprolol Fumarate and Hydrochlorothiazide in Tablet Formulation using Partial Least-Squares, Principal Component Regression Multivariate Calibrations and RP-HPLC Methods
J Anal Pharm Res 2017, 4(6): 00124 Abstract The UV spectrophotometric analysis of a binary mixture containing bisoprolol fumarate (BS) and hydrochlorothiazide (HZ) by using multivariate calibration methods, such as principal component regression (PCR) and partial least-squares regression (PLS-1); and a graphical spectrophotometric method such as second derivative of the ratio spectra 2DD was de...
متن کاملSpectrophotometric method for estimation of bisoprolol fumarate in tablets.
UNLABELLED Bisoprolol fumarate is prescribed for the treatment of hypertension and angina pectoris. AIM The purpose of this study was to develop a simple, sensitive, accurate, and reproducible method for estimation of bisoprolol fumarate in tablets. MATERIAL AND METHODS The proposed method was based on a yellow colored complex formed with tropaeolin 00, extractable in dichloromethane with m...
متن کاملValidated and Stability Indicating Liquid Chromatography Method for Quantification of Bisoprolol Fumarate in Tablet Dosage Form
A simple and accurate liquid chromatographic method was developed and validated for the analysis of bisoprolol fumarate in tablets. Chromatographic separation was achieved on a C18 column utilizing a mobile phase of buffer/acetonitrile (75:25, v/v, pH 5.6) at a flow rate of 1.0 mL/min. The separation was performed at room temperature. Detection was carried out at 226 nm, using a diode array det...
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تاریخ انتشار 2011